Molecular Genetics & Microbiology

Carolyn Mold

Carolyn Mold, Ph.D.

Molecular Genetics and Microbiology
MSC08 4660
1 University of New Mexico
Albuquerque, NM 87131-0001
Office: BMSB 351
Tel: (505) 272-5768
Fax: (505) 272-6029

Keywords: autoimmunity, complement, Fc receptors, innate immunity, C-reactive protein.

Research Interests:         

Proteins of innate immunity including complement, C-reactive protein and serum amyloid P component, their receptors, the FcgR and FcaRI, and the cellular responses they induce. The role of these proteins, receptors and cellular responses in trauma and in systemic autoimmune disease, specifically systemic lupus erythematosus.

Selected Publications

Link to PubMed

Mold, C., B. Rodic-Polic, T.W. Du Clos. 2002. Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fcg receptors. Journal of Immunology 169:7019-7025.

Mold, C, W. Rodriguez, B. Rodic-Polic, and T.W. Du Clos. 2002. C-reactive protein mediates protection from lipopolysaccharide through interactions with Fcg receptors. Journal of Immunology 169:7109-7125.

Rodriguez, W., C. Mold, M. Kataranovski, J. Hutt, LL. Marnell, and T.W. Du Clos. 2005. C-reactive protein reverses ongoing lupus nephritis. Arthritis and Rheumatism, 52:642-650.

Rodriguez, W., C. Mold, L.L. Marnell, J. Hutt, G. J. Silverman, D. Tran, and T. W. Du Clos. 2006. Prevention and reversal of nephritis in MRL/lpr mice with a single injection of C-reactive protein. Arthritis and Rheumatism 54:325-335.

Mold, C. and T.W. Du Clos. 2006. C-reactive protein increases cytokine responses to Streptococcus pneumoniae through interactions with Fcg receptors. Journal of Immunology 176:7598-7604.

Thomas-Rudolph, D., T.W. Du Clos, C.M. Snapper, and C. Mold. 2007. C-reactive protein enhances immunity to Streptococcus pneumoniae by targeting uptake to FcgR on dendritic cells. Journal of Immunology 178:7283-7291.

Lu, J., L.L. Marnell, K.D. Marjon, C. Mold, T.W. Du Clos, and P.D. Sun. 2008. Structural recognition and functional activation of FcgR by innate pentraxins. Nature, 456:989-992.

Marjon, K.D., L.L. Marnell, C. Mold, and T.W. Du Clos. 2009. Macrophages activated by C-reactive protein through FcRI transfer suppression of immune thrombocytopenia. Journal of Immunology 182:1397-1403.

Lu, J., K.D. Marjon, L.L. Marnell, R. Wang, C. Mold, T. W. Du Clos, and P.D. Sun. 2011. Recognition and functional activation of human FcaRI by C-reactive protein. Proceedings of the National Academy of Sciences, USA. 108:4974-4979.

West, S.D., C. Mold. 2012. Monocyte deactivation correlates with injury severity score, but not with heme oxygenase-1 levels in trauma patients. Journal of Surgical Research. 172:5-10.

West, S.D., D. Goldberg, A. Ziegler, M. Krencicki, T.W. Du Clos, and C. Mold. 2012. Transforming growth factor-beta, macrophage colony-stimulating factor  and C-reactive protein levels correlate with CD14(high)CD16+ monocyte induction and activation in trauma patients. PLOS One. 7: e52406.

Mold, C. and T.W. Du Clos. 2013. C-reactive protein inhibits plasmacytoid dendritic cell interferon responses to autoantibody immune complexes. Arthritis and Rheumatism. Apr 10, Epub ahead of print