Dr. Deretic's main contributions to science come from studies by his team on the role of autophagy in infection and immunity. Autophagy, a cytoplasmic pathway for the removal of damaged or surplus organelles, has been previously implicated in cancer, neurodegeneration, development, and aging. Dr. Deretic's group is one of those that made the discovery that autophagic degradation is a major effector and aregulator of innate and adaptive immunity mechanisms for direct elimination of intracellular microbes (such as Mycobacterium tuberculosis and HIV). His current work is on the role of autophagy in immunity and inflammation, interactions with lipid metabolism, and fundamental mechanisms of how selective autophagy is regulated in mammalian cells.
Dr. Deretic is Chair of the Department of Molecular Genetics and Microbiology and Professor of Molecular Genetics and Microbiology, Cell Biology & Physiology, and Neurology at the University of New Mexico School of Medicine. He received his undergraduate, graduate and postdoctoral education in Belgrade, Paris, and Chicago. He was a faculty member at the University of Texas, University of Michigan, and joined the Department of Molecular Genetics and Microbiology, University of New Mexico, in 2001.
For a link to a comprehensive review on autophagy in immunity click here
Mandell MA, Jain A, Arko-Mensah J, Chauhan S, Kimura T, Dinkins C, Silvestri G, Munch J, Kirchhoff F, Simonsen A, Wei Y, Levine B, Johansen T, Deretic V. TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition. Dev Cell. 2014 Aug 5. pii: S1534-5807(14)00402-X. doi: 10.1016/j.devcel.2014.06.013.
Dupont N, Chauhan S, Arko-Mensah, J, Castillo E F, Masedunskas, A, Weigert R, Robenek, H, Proikas-Cezanne, T, and Deretic V. 2014. Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis. Curr Biol 24:609-620.
Deretic V, Saitoh T, Akira S. Autophagy in infection, inflammation and immunity. 2013. Nat Rev Immunol. 13:722-37.
Pilli M, Arko-Mensah J, Ponpuak M, Roberts E, Master S, Mandell MA, Dupont N, Ornatowski W, Jiang S, Bradfute SB, Bruun JA, Hansen TE, Johansen T, Deretic V. 2012. TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation. Immunity. 37:223-34
Castillo EF, Dekonenko A, Arko-Mensah J, Mandell MA, Dupont N, Jiang S, Delgado-Vargas M, Timmins GS, Bhattacharya D, Yang H, Hutt J, Lyons CR, Dobos KM, Deretic V. 2012. Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc Natl Acad Sci U S A. 109:E3168-76.
Dupont, N., Jiang, S., Pilli, M., Ornatowski, W., Bhattacharya, D., and Deretic, V. 2011. Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1beta. Embo J 30, 4701-4711.
Singh, S. B., W. Ornatowski, I. Vergne, J. Naylor, M. Delgado, E. Roberts, M. Ponpuak, S. Master, M. Pilli, E. White, M. Komatsu, and V. Deretic. 2010. Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat Cell Biol 12, 1154-1165.
Ponpuak, M., Davis, A.S., Roberts, E.A., Delgado, M.A., Dinkins, C., Zhao, Z., Virgin, H.W.t., Kyei, G.B., Johansen, T., Vergne, I., and Deretic, V. 2010. Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties. Immunity 32, 329-341.
Deretic, V. 2010. Autophagy in infection. Current opinion in cell biology 22, 252-262.
Vergne, I., E. Roberts, R.E. Elmaoued, V. Tosch, M. A Delgado, T. Proikas-Cezanne, J. Laporte and V. Deretic. 2009. Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy. EMBO J. 28:2244-2258.
Deretic, V., and Levine, B. 2009. Autophagy, Immunity, and Microbial Adaptations. Cell Host and Microbe 5:527-549.
Kyei, G.B., Dinkins, C., Davis, A.S., Roberts, E., Singh, S.B., Dong, C., Wu, L., Kominami, E., Ueno, T., Yamamoto, A., Federico, M., Panganiban, A., Vergne, I., and Deretic., V. 2009. Autophagy pathway intersects with HIV-1 biogenesis and regulates viral yields in macrophages. J Cell Biol 186:255-68.
Delgado-Vargas, M.A., Elmaoued, R.A., David, A.S., Kyei, G., and Deretic, V. 2008. Toll-like receptors control autophagy. EMBO J., 27(7): 1110-21.
Deretic, V., and D. J. Klionsky. 2008. How cells clean house. Scientific American 298:74-81.
Levine B and Deretic. 2007. Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol. 7:767-77.
Harris, J., S. A. De Haro, S. S. Master, J. Keane, E., A. Roberts, M. Delgado, and V. Deretic. 2007. T helper 2 cytokines inhibit autophagic control of intracellular M. tuberculosis. Immunity, 27:505-517.
Singh, S.B., A. Davis, G. A. Taylor, and V. Deretic. 2006. Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria. Science 3 August 2006: 11295771 doi:10.1126/science.1129577
Gutierrez, M. G., S. S. Master, S. B. Singh, G. A. Taylor, M. I. Colombo, and V. Deretic. 2004. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 119:1-20.