Dr. Deretic's main contributions to science come from studies by his team on the role of autophagy in infection and immunity. Autophagy, a cytoplasmic pathway for the removal of damaged or surplus organelles, has been previously implicated in cancer, neurodegeneration, development, and aging. Dr. Deretic's group is one of those that made the discovery that autophagic degradation is a major effector and aregulator of innate and adaptive immunity mechanisms for direct elimination of intracellular microbes (such as Mycobacterium tuberculosis and HIV). His current work is on the role of autophagy in immunity and inflammation, interactions with lipid metabolism, and fundamental mechanisms of how selective autophagy is regulated in mammalian cells.
Dr. Deretic is Chair of the Department of Molecular Genetics and Microbiology and Professor of Molecular Genetics and Microbiology, Cell Biology & Physiology, and Neurology at the University of New Mexico School of Medicine. He received his undergraduate, graduate and postdoctoral education in Belgrade, Paris, and Chicago. He was a faculty member at the University of Texas, University of Michigan, and joined the Department of Molecular Genetics and Microbiology, University of New Mexico, in 2001.
For a link to a comprehensive review on autophagy in immunity click here
TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis. Chauhan S, Kumar S, Jain A, Ponpuak M, Mudd MH, Kimura T, Choi SW, Peters R, Mandell M, Bruun JA, Johansen T, Deretic V. Dev Cell. 2016 Sep 28 doi: 10.1016/j.devcel.2016.08.003.
Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential. Chauhan S, Ahmed Z, Bradfute SB, Arko-Mensah J, Mandell MA, Won Choi S, Kimura T, Blanchet F, Waller A, Mudd MH, Jiang S, Sklar L, Timmins GS, Maphis N, Bhaskar K, Piguet V, Deretic V. Nat Commun. 2015 Oct 27;6:8620. doi: 10.1038/ncomms9620.
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. Kimura T, Jain A, Choi SW, Mandell MA, Schroder K, Johansen T, Deretic V. J Cell Biol. 2015 Sep 14;210(6):973-89.
Therapeutic targeting of autophagy in neurodegenerative and infectious diseases. Rubinsztein DC, Bento CF, Deretic V. J Exp Med. 2015 Jun 29;212(7):979-90.
IRGM governs the core autophagy machinery to conduct antimicrobial defense. Chauhan S, Mandell MA, Deretic V. Mol Cell. 2015 May 7;58(3):507-21.
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. Mandell MA, Jain A, Arko-Mensah J, Chauhan S, Kimura T, Dinkins C, Silvestri G, Münch J, Kirchhoff F, Simonsen A, Wei Y, Levine B, Johansen T, Deretic V. Dev Cell. 2014 Aug 25;30(4):394-409.
Autophagy in infection, inflammation and immunity. Deretic V, Saitoh T, Akira S. Nat Rev Immunol. 2013 Oct;13(10):722-37.
Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Castillo EF, Dekonenko A, Arko-Mensah J, Mandell MA, Dupont N, Jiang S, Delgado-Vargas M, Timmins GS, Bhattacharya D, Yang H, Hutt J, Lyons CR, Dobos KM, Deretic V. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3168-76.
TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation. Pilli M, Arko-Mensah J, Ponpuak M, Roberts E, Master S, Mandell MA, Dupont N, Ornatowski W, Jiang S, Bradfute SB, Bruun JA, Hansen TE, Johansen T, Deretic V. Immunity. 2012 Aug 24;37(2):223-34.
Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β. Dupont N, Jiang S, Pilli M, Ornatowski W, Bhattacharya D, Deretic V. EMBO J. 2011 Nov 8;30(23):4701-11.
Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria.Singh SB, Ornatowski W, Vergne I, Naylor J, Delgado M, Roberts E, Ponpuak M, Master S, Pilli M, White E, Komatsu M, Deretic V. Nat Cell Biol. 2010 Dec;12(12):1154-65.
Human IRGM induces autophagy to eliminate intracellular mycobacteria. Singh SB, Davis AS, Taylor GA, Deretic V. Science. 2006 Sep 8;313(5792):1438-41.
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Gutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI, Deretic V. Cell. 2004 Dec 17;119(6):753-66.