MSC 08 4660
1 University of New Mexico
Albuquerque, NM 87131
Physical Location:
Basic Medical Sciences Building
Room 347
Phone: (505) 272-9374
Fax: (505) 272-6029
SAnGarcia@salud.unm.edu
Research Interests
Dr. O'Rourke is a Research Assistant Professor in MGM and works closely with Bryce Chackerian and David Peabody in the department to develop Virus-like Particle based vaccines for a variety of infectious diseases.
Selected Publications
Link to PubMedRourke, J. P., Daly, S. M., Peabody, D. S., Chackerian, B., and P. R. Hall (2014). Development of a Mimotope Vaccine Targeting the Staphylococcus aureus Quorum Sensing Pathway. PLoS One. 2014 Nov 7;9(11):e111198.
Zhou YE, O'Rourke JP, Edwards JS, Ness SA. Single molecule analysis of c-myb alternative splicing reveals novel classifiers for precursor B-ALL. PLoS One. 2011;6(8):e22880. Epub 2011 Aug 11.
Quintana AM, Zhou YE, Pena JJ, O'Rourke JP, Ness SA. Dramatic repositioning of c-Myb to different promoters during the cell cycle observed by combining cell sorting with chromatin immunoprecipitation.PLoS One. 2011 Feb 22;6(2):e17362.
Quintana AM, Liu F, O'Rourke JP, Ness SA. Identification and regulation of c-Myb target genes in MCF-7 cells. BMC Cancer. 2011 Jan 25;11:30.
O'Rourke JP, Ness SA. Alternative RNA splicing produces multiple forms of c-Myb with unique transcriptional activities. Mol Cell Biol. 2008 Mar;28(6):2091-101. Epub 2008 Jan 14.
Liu F, Lei W, O’Rourke JP, Ness SA. Oncogenic Mutations Cause Dramatic, Qualitative Changes in the Transcriptional Activity of c-Myb. Oncogene. 2006 Feb 2;25(5):795-805.
Rourke JP, Olsen JC, Bunnell BA. Optimization of Equine Infectious Anemia Derived Vectors for Hematopoietic Cell Lineage Gene Transfer. Gene Ther 2005 Jan;12(1):22-29.
Rourke JP, Hiraragi H, Urban K, Patel M, Olsen JC, Bunnell BA. Analysis of gene transfer and expression in skeletal muscle using enhanced EIAV lentivirus vectors. Mol Ther. 2003 May;7(5):632-9.
Rourke JP, Newbound GC, Kohn DB, Olsen JC, Bunnell, BA. Comparison of Gene Transfer Efficiency and Gene Expression with EIAV and HIV-1 Derived Lentivirus Vectors. J. Virology. 2002 Feb;76(3): 1510-1515.
O'Rourke JP, Tarantal AF, Case SS, Newbound GC, Li J, Lee CI, Baskin CR, Kohn DB, Bunnell BA. Rhesus monkey model for fetal gene transfer: studies with retroviral- based vector systems. Mol Ther 2001 Feb;3(2):128-38.
Newbound GC, Cooper JR, O'Rourke JP, Baskin CR, Bunnell BA. Analysis of gene transfer efficiency of retrovirus producer cell transplantation for in situ gene transfer to hematopoietic cells. Exp Hematol 2001 Feb;29(2):163-73.
Newbound GC, O'Rourke JP, Collins ND, Andrews JM, DeWille J, Lairmore MD. Repression of tax-mediated human t-lymphotropic virus type 1 transcription by inducible cAMP early repressor (ICER) protein in peripheral blood mononuclear cells. J Med Virol 2000 Oct;62(2):286-92.
Hutt JA, O'Rourke JP, DeWille J. Signal transducer and activator of transcription 3 activates CCAAT enhancer-binding protein delta gene transcription in G0 growth-arrested mouse mammary epithelial cells and in involuting mouse mammary gland. J Biol Chem 2000 Sep 15;275(37):29123-31.
O'Rourke JP, Hutt JA, DeWille J. Transcriptional regulation of C/EBP delta in G0 growth-arrested mouse mammary epithelial cells. Biochem Biophys Res Commun 1999 Sep 7;262(3):696-701.
O'Rourke JP, Newbound GC, Hutt JA, DeWille J. CCAAT/enhancer-binding protein delta regulates mammary epithelial cell G0 growth arrest and apoptosis. J Biol Chem 1999 Jun 4;274(23):16582-9.
Newbound GC, O'Rourke JP, Collins ND, DeWille J, Lairmore MD. Comparison of HTLV-I basal transcription and expression of CREB/ATF-1/CREM family members in peripheral blood mononuclear cells and Jurkat T cells. J Acquir Immune Defic Syndr Hum Retrovirol 1999 Jan 1;20(1):1-10.
Werkmeister JR, Blomme EA, Weckmann MT, Grone A, McCauley LK, Wade AB, O'Rourke JP, Capen CC, Rosol TJ. Effect of transforming growth factor-beta1 on parathyroid hormone-related protein secretion and mRNA expression by normal human keratinocytes in vitro. Endocrine 1998 Jun;8(3):291-9.
O'Rourke JP, Yuan R, DeWille J. CCAAT/enhancer-binding protein-delta (C/EBP-delta) is induced in growth-arrested mouse mammary epithelial cells. J Biol Chem 1997 Mar 7;272(10):6291-6.
Newbound GC, Andrews JM, O'Rourke JP, Brady JN, Lairmore MD. Human T-cell lymphotropic virus type 1 Tax mediates enhanced transcription in CD4+ T lymphocytes. J Virol 1996 Apr;70(4):2101-6.