Suresh Kumar, Ph.D.

Suresh Kumar

Research Assistant Professor
Department of Molecular Genetics and Microbiology
MSC08 4660
1 University of New Mexico
Albuquerque, NM 87131-0001
 
Office: Fitz 385
Tel: (505) 272-3179
Fax: (505) 272-6029
E-mail: SuKumar@salud.unm.edu

Keywords: Autophagy, SNARE proteins

Research Interests

Autophagy is a cellular homeostatic and quality control process that delivers damaged organelles, protein aggregates and invading pathogen to lysosomes for their degradation. Autophagy has very important roles in various human pathologies, including infectious diseases, cancer and neurodegeneration, and its modulation has considerable potential as a therapeutic approach. The molecular mechanism of autophagy is well understood in yeast. However, the mechanism underlying the mammalian autophagy is not fully understood and there are several unanswered questions which need to be addressed.

My research is focused on understanding the role of SNARE protein Stx17 and its partner SNAREs in autophagy. Our recent work shows that Human Immunity related GTPase (IRGM) coordinates with mammalian Atg8 proteins to recruit Stx17 to autophagic membranes (J Cell Biol. 2018). In a more recent study, we identified the role of Stx17 in the formation of mammalian pre-autophagosomal structures (Dev Cell. 2019). We demonstrated that the immunoregulatory kinase TANK binding kinase 1 (TBK1) phosphorylates Stx17 and this phosphorylation is important to regulate the formation of pre-autophagosomal structures and consequent autophagy. My future studies will focus on studying the role of Stx17 and its SNARE partners in understanding the membrane dynamics in autophagy. I am also interested in investigating the role of Stx17 in non-canonical autophagy. Overall, these studies will help in better understanding the membrane dynamics in autophagy. My research is performed in close collaboration with Dr. Vojo Deretic.

Selected Publications

Link to PubMed

Suresh Kumar, Yuexi Gu, Yakubu Princely Abudu, Jack-Ansgar Bruun, Ashish Jain, Farzin    Farzam, Michal Mudd, Jan Haug Anonsen,Tor Erik Rusten, Gary Kasof, Nicholas Ktistakis, Keith A.  Lidke,Terje Johansen, and Vojo Deretic. Phosphorylation of Syntaxin 17 by TBK1 controls autophagy initiation. Developmental Cell. doi: 10.1016/j.devcel.2019.01.027

Jingyue Jia, Yakubu Princely Abudu, Aurore Claude-Taupin, Yuexi Gu, Suresh Kumar, Seong Won Choi, Ryan Peters, Michal H. Mudd, Lee Allers, Michelle Salemi, Brett Phinney, Terje Johansen, Vojo Deretic. Galectins control MTOR and AMPK in response to lysosomal damage to induce autophagy. Autophagy. 2019;15:169-171. doi: 10.1080/15548627.2018.1505155.

Jingyue Jia, Yakubu Princely Abudu, Aurore Claude-Taupin, Yuexi Gu, Suresh Kumar, Seong Won Choi, Ryan Peters, Michal H. Mudd, Lee Allers, Michelle Salemi, Brett Phinney, Terje Johansen, Vojo Deretic: Galectins Control mTOR in Response to Endomembrane Damage. Molecular Cell 04/2018; 70(1):120-135.e8., DOI:10.1016/j.molcel.2018.03.009

Suresh Kumar, Ashish Jain, Farzin Farzam, Jingyue Jia, Yuexi Gu, Seong Won Choi, Michal H. Mudd, Aurore Claude-Taupin, Michael J. Wester, Keith A. Lidke, Tor-Erik Rusten, Vojo Deretic: Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins. The Journal of Cell Biology 02/2018; 217(3):jcb.201708039., DOI:10.1083/jcb.201708039.

Suresh Kumar, Santosh Chauhan, Ashish Jain, Marisa Ponpuak, Seong Won Choi, Michal Mudd, Ryan Peters, Michael A Mandell, Terje Johansen, Vojo Deretic: Galectins and TRIMs directly interact and orchestrate autophagic response to endomembrane damage. Autophagy 04/2017; 13(6)., DOI:10.1080/15548627.2017.1307487

Tomonori Kimura, Jingyue Jia, Aurore Claude-Taupin, Suresh Kumar, Seong Won Choi, Yuexi Gu, Michal Mudd, Nicolas Dupont, Shanya Jiang, Ryan Peters, Farzin Farzam, Ashish Jain, Keith A Lidke, Christopher M Adams, Terje Johansen, Vojo Deretic: Cellular and molecular mechanism for secretory autophagy. Autophagy 04/2017; 13(6)., DOI:10.1080/15548627.2017.1307486

Michael A. Mandell, Ashish Jain, Suresh Kumar, Moriah J. Castleman, Tahira Anwar, Eeva-Liisa Eskelinen, Terje Johansen, Rytis Prekeris, Vojo Deretic: Correction: TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation. Journal of Cell Science 03/2017; 130(6):1194-1194., DOI:10.1242/jcs.202499

Tomonori Kimura, Jingyue Jia, Suresh Kumar, Seong Won Choi, Yuexi Gu, Michal Mudd, Nicolas Dupont, Shanya Jiang, Ryan Peters, Farzin Farzam, Ashish Jain, Keith A Lidke, Christopher M Adams, Terje Johansen, Vojo Deretic: Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy. The EMBO Journal 12/2016; 36(1):e201695081., DOI:10.15252/embj.201695081

Santosh Chauhan*, Suresh Kumar*, Ashish Jain*, Marisa Ponpuak, Michal H. Mudd, Tomonori Kimura, Seong Won Choi, Ryan Peters, Michael Mandell, Jack-Ansgar Bruun, Terje Johansen, Vojo Deretic: TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis. Developmental Cell 09/2016; 39(1)., DOI:10.1016/j.devcel.2016.08.003. *equal contribution

Anup S. Pathania, Santosh K. Guru, Suresh Kumar, Ashok Kumar, Masroor Ahmad, Shashi Bhushan, Parduman R. Sharma, Priya Mahajan, Bhahwal A. Shah, Simmi Sharma, Amit Nargotra, Ram Vishwakarma, Hasan Korkaya, Fayaz Malik: Interplay between cell cycle and autophagy induced by boswellic acid analog. Scientific Reports 09/2016; 6:33146., DOI:10.1038/srep33146

Santosh Kumar Guru, Anup Singh Pathania, Suresh Kumar, Deshidi Ramesh, Manjeet Kumar, Satiander Rana, Ajay Kumar, Fayaz Malik, P. R. Sharma, B. K. Chandan, Sundeep Jaglan, J. P. Sharma, Bhahwal Ali Shah, Sheikh Abdullah Tasduq, Surrinder K Lattoo, Abdul Faruk, A. K. Saxena, R. A. Vishwakarma, Shashi Bhushan: Secalonic Acid-D represses HIF1α/VEGF-mediated angiogenesis by regulating the Akt/mTOR/p70S6K signaling cascade. Cancer Research 05/2015; 14(14)., DOI:10.1158/0008-5472.CAN-14-2312

Suresh Kumar, Santosh Guru, Shashi Bhushan: A novel quinolinebased second-generation mTOR inhibitor that induces apoptosis and disruptsPI3K-Akt-mTOR signaling in human leukemia HL-60 cells.. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) 04/2015;

Anup S Pathania, Zahoor A Wani, Santosh K Guru, Suresh Kumar, Shashi Bhushan, Ajay Kumar, Fayaz Malik: The anti-angiogenic and cytotoxic effects of the boswellic acid analog BA145 are potentiated by autophagy inhibitors. Molecular Cancer 01/2015; 14(1)., DOI:10.1186/1476-4598-14-6

Suresh Kumar, Santosh Kumar Guru, Anup Singh Pathania, Ajay Kumar: Fascaplysin Induces Caspase Mediated Crosstalk Between Apoptosis and Autophagy Through the Inhibition of PI3K/ AKT/mTOR Signaling Cascade in Human Leukemia HL-60 Cells. Journal of Cellular Biochemistry 01/2015; 116(6)., DOI:10.1002/jcb.25053

Suresh Kumar, Santosh K Guru, Anup S Pathania, Ajay Kumar, Shashi Bhushan, Fayaz Malik: Autophagy triggered by magnolol derivative negatively regulates angiogenesis. Cell Death & Disease 10/2013; 4(10):e889., DOI:10.1038/cddis.2013.399

Mallikharjuna Rao Lambu, Suresh Kumar, Syed Khalid Yousuf, Deepak K Sharma, Altaf Hussain, Ajay Kumar, Fayaz Malik, Debaraj Mukherjee: Medicinal Chemistry of Dihydropyran-Based Medium Ring Macrolides Related to Aspergillides: Selective Inhibition of PI3Kα. Journal of Medicinal Chemistry 07/2013; 56(15)., DOI:10.1021/jm400515c

Suresh Kumar, Ajay Kumar, Anup Singh Pathania, Santosh Kumar Guru, Srinivas Jada, Parduman Raj Sharma, Shashi Bhushan, Ajit Kumar Saxena, H.M. Sampath Kumar, Fayaz Malik: Tiron and trolox potentiate the autophagic cell death induced by magnolol analog Ery5 by activation of Bax in HL-60 cells. APOPTOSIS 03/2013; 18., DOI:10.1007/s10495-013-0805-y.