Antibodies are a critical component of the immune system with both beneficial and harmful roles in infectious diseases, cancer, and autoimmune disease. Knowing the specific targets of antibodies can lead to prophylactic or therapeutic vaccines, new diagnostic or prognostic tests, and/or the development of new drugs.
Dr. Frietze’s research is focused on three goals:
Dr. Frietze earned her B.S. in Biological Sciences from Central Washington University in Ellensburg, WA and her PhD in Biomedical Sciences from the University of New Mexico where she did her dissertation research under the direction of Dr. Adriana Kajon at the Lovelace Respiratory Research Institute. She also has a Graduate Certificate in University Science Teaching from the University of New Mexico and has an interest in adapting Problem-Based Learning to all levels of science education. She collaborates closely with Dr. Bryce Chackerian and Dr. David Peabody in the MGM Department.
Frietze, KM, Pascale, J.M., Moreno, B., Chackerian, B., and D.S. Peabody (2017). Pathogen-specific deep sequence-coupled biopanning: A method for surveying human antibody responses. PLoS One 2017 Feb 2;12(2):e0171511. doi: 10.1371/journal.pone.0171511.
Daly, S.M, Joyner, J.A., Triplett, K.D., Elmore, B.O., Pokhrel, S., Frietze, K.M., Peabody, D.S., Chackerian, B., and P.R. Hall (2017). VLP-based vaccine induces immune control of Staphylococcus aureus virulence regulation. Scientific Reports 7, Article number 637 (2017).
Chackerian B, Frietze KM. Moving towards a new class of vaccines for non-infectious chronic diseases. Expert Rev Vaccines. 2016 May;15(5):561-3.
Frietze KM, Peabody DS, Chackerian B. Engineering virus-like particles as vaccine platforms. Curr Opin Virol. 2016 Mar 29;18:44-49.
Frietze KM, Roden RB, Lee JH, Shi Y, Peabody DS, Chackerian B. Identification of Anti-CA125 Antibody Responses in Ovarian Cancer Patients by a Novel Deep Sequence-Coupled Biopanning Platform. Cancer Immunol Res. 2016 Feb;4(2):157-64.
Crossey E, Frietze K, Narum DL, Peabody DS, Chackerian B. Identification of an Immunogenic Mimic of a Conserved Epitope on the Plasmodium falciparum Blood Stage Antigen AMA1 Using Virus-Like Particle (VLP) Peptide Display. PLoS One. 2015 Jul 6;10(7):e0132560.
Frietze KM, Campos SK, Kajon AE. No evidence of a death-like function for species B1 human adenovirus type 3 E3-9K during A549 cell line infection. BMC Res Notes. 2012 Aug 11;5:429.
Frietze KM, Campos SK, Kajon AE. Open reading frame E3-10.9K of subspecies B1 human adenoviruses encodes a family of late orthologous proteins that vary in their predicted structural features and subcellular localization. J Virol. 2010 Nov;84(21):11310-22.